MP39-17 MECP2 SILENCING IN HIGH GRADE BLADDER CANCER DERIVED HTB-5 CELL LINE AFFECTS CELLULAR PROLIFERATION AND MIGRATORY ABILITY
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The Effects of NDRG2 Overexpression on Cell Proliferation and Invasiveness of SW48 Colorectal Cancer Cell Line
Background: Colorectal cancer (CRC) is one of the most common causes of cancer-related death in the world. The expression of N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in CRC. The aim of this study was to investigate the effect of NDRG2 overexpression on cell proliferation and invasive potential of SW48 cells.Methods: SW48 cells were transfected with a plasmid overexpressing ND...
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Transforming growth factor betas are multifunctional polypeptides in the cytokine superfamily. They have a growth inhibitory role on hemopoietic progenitor cells in semisolid colony assay as well as in long-term bone-marrow culture. TGF - β2 represses stromal cells, stem cell factor gene transcription, and decreases the stability of c-kit transcripts in hemopoietic cells. TGF-β also modulat...
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© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau and epididymides from rats in all groups were removed, weighed and subjected to histological examination and semen analysis after treatment. Oxidative stress was assessed by measuring 8-hydroxy-20-deoxyguanosine (8-OHdG) and superoxide dismutase (SOD). Results: The results showed that KH...
متن کاملSilencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.
Alterations in genomic CpG methylation patterns have been found to be associated with cell transformation and neoplasia. Although it is recognized that methylation of CpG residues negatively regulates gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determine whether the two well characterized proteins MeCP2 (methyl-CpG-binding prote...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2014
ISSN: 0022-5347,1527-3792
DOI: 10.1016/j.juro.2014.02.1332